Recent advance in extracellular space changes and mechanisms in peritumor edema regions of brain gliomas
10.3760/cma.j.cn115354-20201211-00961
- VernacularTitle:脑胶质瘤瘤周水肿区细胞外间隙改变及机制研究进展
- Author:
Kaiming MA
1
;
Jun YANG
Author Information
1. 北京大学第三医院神经外科，北京 100191
- Keywords:
Glioma;
Peritumoral brain edema;
Extracellular space;
Tumour microenvironment
- From:
Chinese Journal of Neuromedicine
2022;21(3):242-248
- CountryChina
- Language:Chinese
-
Abstract:
As one of the refractory tumors in the world, brain glioma has increased incidence year by year in recent years. Peritumoral brain edema (PTBE), as one of the main clinical features of glioma, has proved to be the main source of recurrent tumor infiltrating area. There are significant changes in the interstitial fluid drainage partition system and the steady state of brain partitions in the extracellular space (ECS) of this area, embodied in ECS space structure (volume fraction and tortuosity), tissue fluid drainage, material diffusion, and space physical polarity. And this process involves a series of changes of molecular biology mechanisms. This paper focuses on the specific changes and related mechanisms of ECS in PTBE region of brain glioma from the perspective of the brain cells microenvironment, so as to further explore the pathophysiological changes in this region and provide theoretical basis for the new model of diagnosis and treatment of glioma based on ECS.
