Regulation mechanism and targeted therapy of transcytosis in blood-brain barrier after cerebral ischemia
10.3760/cma.j.cn115354-20201103-00868
- VernacularTitle:缺血性脑卒中后血脑屏障内皮跨细胞转运的调控机制及靶向治疗
- Author:
Min ZHOU
1
;
Zhili CHEN
;
Lili ZHANG
;
Boli ZHANG
Author Information
1. 天津医科大学总医院中医科，天津 300052
- Keywords:
Ischemic stroke;
Blood-brain barrier;
Ttranscytosis;
Caveolae
- From:
Chinese Journal of Neuromedicine
2022;21(2):189-194
- CountryChina
- Language:Chinese
-
Abstract:
The changes of blood-brain barrier (BBB) permeability after ischemic stroke (IS) have important effects on brain edema, brain immune inflammation, hemorrhage transformation and angiogenesis and recanalization in convalescence. Recent studies have shown that the high permeability of BBB is gradually caused by significant up-regulation of endothelial transcytosis (transcellular pathway) several hours after IS and the disintegration of tight junctions (paracellular pathway) several days after IS; the up-regulation of transcytosis is earlier than tight junction destruction and independent of tight junction destruction. Therefore, maintaining a low endothelial transcytosis rate and maintaining a complete tight junction play key roles in the physiological function and brain homeostasis of BBB. The transcellular transport occurrence and regulation have become new topics in targeted therapy of BBB after IS. This review briefly summarizes the biological classification and cellular structure of endothelial transcytosis in BBB, reviews the molecular mechanisms that have been found in recent years to regulate this pathway, and summarizes the post-stroke therapeutic drugs and methods that target this pathway, besides, the relevant treatment strategies and research entry points are prospected.
