Recent advance in molecular mechanism of neural stem cell homing after ischemic stroke
10.3760/cma.j.cn115354-20201201-00938
- VernacularTitle:缺血性脑卒中后神经干细胞归巢分子调控机制的研究进展
- Author:
Zhaodi YUE
1
;
Yanyan YIN
;
Fangqi WANG
;
Shaohong YU
Author Information
1. 山东中医药大学康复医学院，济南 250355
- Keywords:
Ischemic stroke;
Neural stem cell;
Homing;
Molecular mechanism
- From:
Chinese Journal of Neuromedicine
2021;20(5):519-524
- CountryChina
- Language:Chinese
-
Abstract:
The irreversibility of nerve cell injury is the main pathological basis of disability in stroke patients. In recent years, it has been found that neural stem cells (NSCs) with multi-directional differentiation potential and self-renewal capacity can proliferate under stress in the adult central nervous system, migrate to the injured area and differentiate into neural cells, thus participating in the repair of nerve injury. However, due to the limited number of homing stem cells, it is difficult to make up for the vacancy caused by the massive necrosis of neurons. This paper reviews the molecular mechanism of NSCs homing under ischemia and hypoxia, and explains the application prospect of NSCs in ischemic stroke.
