Recent advance in pathogenesis of chronic inflammatory demyelinating polyradiculoneuropathy
10.3760/cma.j.cn115354-20190715-00402
- VernacularTitle:慢性炎性脱髓鞘性多发性神经根神经病发病机制的研究进展
- Author:
Yuan FENG
1
;
Zuneng LU
Author Information
1. 武汉大学人民医院神经内科，武汉，430060
- Keywords:
Chronic inflammatory demyelinating polyradiculoneuropathy;
Membrane attack complex;
Contactin-1;
Bundle protein 155;
Bundle protein 186
- From:
Chinese Journal of Neuromedicine
2020;19(3):316-319
- CountryChina
- Language:Chinese
-
Abstract:
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a motor-sensory demyelinating neuropathy mediated by immunity. The pathogenesis is still unclear, and the clinical manifestations are complex. Its diagnoses are difficult, and the treatment effect is not good. At present, most studies consider it to be an autoimmune disease, but the pathogenic antigen and its target to the immune damage mechanism of the disease are still unclear. In this paper, we review the literature on the pathogenesis of CIDP in recent years, and introduce the specific mechanisms which cause CIDP from cellular and humoral immunity.
