A Meta analysis of association between CCDC26 rs4295627 single nucleotide polymorphism and glioma susceptibility
10.3760/cma.j.issn.1671-8925.2017.03.003
- VernacularTitle:CCDC26基因rs4295627单核苷酸多态性与胶质瘤易感性关系的Meta分析
- Author:
Xiang WANG
1
;
Ce ZHANG
;
Qingzhong LI
;
Xiuming ZHOU
;
Weiping LI
Author Information
1. 安徽医科大学附属深圳市第二人民医院临床医学院
- Keywords:
Coiled-coil domain-containing 26;
Glioma;
Gene polymorphism;
Meta analysis
- From:
Chinese Journal of Neuromedicine
2017;16(3):228-232
- CountryChina
- Language:Chinese
-
Abstract:
Objective To certify the relationship between coiled-coil domain-containing 26 (CCDC26) rs4295627 polymorphism and glioma susceptibility by a Meta analysis.Methods Several databases as PubMed,CBM,CNKI and Wanfang Databases were searched;all papers were searched from the date of establishment to April 1,2016.All case-control studies of CCDC26 rs4295627 polymorphism and glioma were collected according to the inclusion and exclusion criteria.The quality of the included trials was assessed and a Meta analysis was performed by State 12.0 software.Results A total of 16 case-control studies involving 5,356 cases and 8,874 controls were enrolled.The results of Meta analyses showed a significant relation between CCDC26 rs4295627 polymorphism and glioma susceptibility (B vs.A:odds ratio [OR]=1.322,95％CI=1.174-1.489,P=0.000;BA vs.AA:OR=1.330,95％CI=1.204-1.470,P=0.000;BA+BB vs.AA:OR=1.366,95％CI=1.212-1.539,P=0.001;BB vs.AA:OR=1.751,95％CI=1.270-2.413,P=0.001;BB vs.BA+AA:OR=1.592,95％CI:1.181-2.145,P=0.002).In the stratification analysis by ethnicity,a significant association between CCDC26 rs4295627 polymorphism and glioma susceptibility in Caucasian population was covered (B vs.A:OR=1.344,95％CI=1.225-1.476,P=0.000;BA vs.AA:OR=1.338,95％CI:1.244-1.439,P=0.000;BA+BB vs.AA:OR=1.381,95％CI:1.264-1.508,P=0.000;BB vs.AA:OR=1.906,95％CI:1.370-2.651,P=0.000).Conclusion The CCDC26 rs4295627 polymorphism has strong association with glioma susceptibility,which can be considered as a biomarker for the diagnosis and screening of glioma patients.
