Relationship of carotid atherosclerosis with phosphoenolpyruvate carboxykinase gene-exon 4 144 polymorphism
10.3760/cma.j.issn.1671-8925.2017.02.011
- VernacularTitle:颈动脉粥样硬化与PCK1基因第4外显子144位点多态性的关系研究
- Author:
Qin LIU
1
;
Lidong LIU
;
Ming SHAO
Author Information
1. 广州医科大学附属第一医院神经内科
- Keywords:
Carotid atherosclerosis;
Phosphoenolpyruvate carboxykinase gene 1;
Polymorphism
- From:
Chinese Journal of Neuromedicine
2017;16(2):161-166
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship of carotid atherosclerosis with phosphoenolpyruvate carboxykinase gene 1 (PCK1) exon 4 144 polymorphism in southern Han Chinese population.Methods Ninety-five patients with carotid atherosclerosis confirmed by carotid artery ultrasound in our hospital fiom May 2012 to February 2013 and 106 healthy physical examination subjects (control group) at the same time period were chosen in our study;genetic polymorphism of exon-4 144 variant of PCK1 was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP);trig1yceride (TG),total cholesterol (TC),high density lipoprotein cholesteml (HDL-C),low density lipoproteill cholesterol (LDL-C) and fasting blood glucose (FPG),glycosylated hemoglobin (HbA1C) and postprandial 2-h blood glucose (HPG) levels were detected.Results (1) The exon-4 144 genotypes (GC,GG and CC) and G and C allele frequency distribution showed no statistical differences between the patient group and control group (x2=2.243,P=0.317;x2=1.021,P=0.352).(2) In the carotid atherosclerosis group and the control group,there was no significant difference in blood glucose and blood lipid indexes among each genotypes of the fourth exon 144.(3) Hypertension history,TC and HPG were the risk factors of carotid atherosclerosis (OR=2.473,P=0.001,95％CI:0.349-0.862;OR=0.816,P=-0.031,95％CI:0.677-0.936;OR=2.201,P=0.004,95％CI:1.803-9.772).Conclusion PCK1 of exon 4 144 G/C gene polymorphism may not be risk factor for carotid atherosclerosis.
