Application value of adjuvant inhalation of hyperbaric oxygen in viability and life quality of postoperative patients with malignant gliomas
10.3760/cma.j.issn.1671-8925.2014.07.003
- VernacularTitle:同步高压氧在脑胶质瘤术后辅助治疗中的应用价值研究
- Author:
Xiaoxiang WU
1
;
Zhiwei HUANG
;
Shengjun LIU
;
Shuai YANG
Author Information
1. 广州军区广州总医院附属第一五七医院神经外科
- Keywords:
Glioma;
Chemomdiotherapy;
Hyperbaric oxygen;
Viability;
Life quality
- From:
Chinese Journal of Neuromedicine
2014;13(7):659-662
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the influence of chemoradiotherapy combined with inhalation of hyperbaric oxygen in short-term therapeutic effectiveness,viability and quality of life of postoperative patients with malignant gliomas.Methods A total of 86 patients with malignant gliomas,admitted to our hospital from January 2009 to December 2013,were chosen in our study; according to the wishes of patients and their families,all patients were divided into two groups:chemoradiotherapy combined with inhalation of hyperbaric oxygen group (n=47) and chemoradiotherapy group (n=39).Chemotherapy regimens were given:temozolomide of 150 mg/m2 body surface area at the first period once daily for a consecutive five days and temozolomide of 200 mg/m2 body surface area since the second period once daily for consecutive five days.Hyperbaric oxygen therapy was given with duration of 60 min at pressure of 2.8 atm.Conventional radiotherapy (6000 cGy/30F) was given in both groups.WHO established solid tumor chemosensitivity criteria was used to evaluate the effective rate of total symptoms,and activity of daily living (ADL) scale and F-36 scale were employed to evaluate the viability and life quality before and three and six months after the intervention.Results The effective rate of total symptoms,ratio of ADL＞60 points in chemoradiotherapy combined with inhalation of hyperbaric oxygen group 3 and 6 months after treatment were 95.74 ％,53.2％ and 72.3％,which were significantly higher than those in the chemoradiotherapy group (58.97 ％,30.8％ and 48.7％,P＜0.05).The scores of all the items of SF-36 scale in chemoradiotherapy combined with inhalation of hyperbaric oxygen group 3 and 6 months after treatment were significantly higher than those in the chemoradiotherapy group (P＜0.05).Conclusion Inhalation of hyperbaric oxygen can significantly improve short-term therapeutic effectiveness,survival duration,viability and quality of life of postoperative patients with malignant gliomas,and obviously improve the prognosis of patients.
