Causal relationship between periodontitis and asthma:a two-sample Mendelian randomization study
10.12016/j.issn.2096-1456.2024.08.005
- VernacularTitle:牙周炎与哮喘的因果关系:一项两样本孟德尔随机化研究
- Author:
Qiwei CHEN
1
;
Ting LIU
;
Yang CAI
Author Information
1. 贵州医科大学口腔医学院,贵州 贵阳(550000)
- Keywords:
periodontitis;
asthma;
Mendelian randomization;
genome-wide-association study;
single nucleo-tide polymorphism;
causal association;
bidirectional casual association;
instrumental variable;
sensitivity analysis
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2024;32(8):606-613
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the bidirectional causal relationships between periodontitis and asthma using the two-sample Mendelian randomization(MR)method to provide a basis for exploring the etiology and formulating preven-tive and therapeutic measures of periodontitis and asthma.Methods We performed two-sample bidirectional Mende-lian randomization analysis using publicly released European genome-wide association studies(GWAS)statistics for periodontitis(n=34 615)and asthma(n=408 422).The inverse variance weighted(IVW)method was employed as the main approach to estimate the bidirectional causal relationships between periodontitis and asthma.In addition,weighted median(WM),MR-Egger regression,maximum likelihood,and Mendelian randomization robust adjusted profile score(MR-RAPS)were used as supplementary analyses.Sensitivity analyses were conducted using Cochran's Q test,Mende-lian randomization pleiotropy residual sum and outlier(MR-PRESSO),and leave-one-out analysis.Results A total of 12 and 43 single-nucleotide polymorphisms(SNPs)were included as instrumental variables for periodontitis and asthma,respectively.The results of IVW,WM,MR-Egger regression,maximum likelihood,and MR-RAPS showed that periodon-titis was not causally related to the risk of asthma(IVW:OR:1.003,95%CI:0.973-1.035,P=0.828,WM:OR:0.990,95%CI:0.951-1.031,P=0.641;MR-Egger regression:OR:0.988,95%CI:0.960-1.028,P=0.573;maximum likeli-hood:OR:1.003,95%CI:0.972-1.035,P=0.834;MR-RAPS:OR:1.002,95%CI:0.970-1.036,P=0.890)among the European population,and no causal effect of asthma on periodontitis was found(IVW:OR:1.021,95%CI:0.938-1.111,P=0.633,WM:OR:1.011,95%CI:0.894-1.142,P=0.866;MR-Egger regression:OR:1.042,95%CI:0.824-1.319,P=0.731;maximum likelihood:OR:1.021,95%CI:0.938-1.112,P=0.631;MR-RAPS:OR:1.017,95%CI:0.931-1.110,P=0.713)among the European population.Cochran's Q test showed no heterogeneity among the included in-strumental variables,MR-PRESSO test found no horizontal pleiotropy,and the leave-one-out method did not identify out-lier SNPs.Conclusion The results of this study,based on European genetic data,do not support a bidirectional causal association between periodontitis and asthma in the European population.
- Full text:2024062710350071222牙周炎与哮喘的因果关系 一项两样本孟德尔随机化研究.pdf
