Serum proteomics of different symptom subtypes of obstructive sleep apnea
10.19845/j.cnki.zfysjjbzz.2023.0050
- VernacularTitle:阻塞性睡眠呼吸暂停不同症状亚型患者血清蛋白质组学分析
- Author:
Liping ZHANG
1
;
Changjun SU
1
Author Information
1. Department of Neurology,The Second Affiliated Hospital of Air Force Medical University of PLA,Xi an 710038,China
- Publication Type:Journal Article
- Keywords:
Obstructive sleep apnea;
Excessive daytime sleepiness;
Insomnia;
Proteomics
- From:
Journal of Apoplexy and Nervous Diseases
2023;40(3):195-201
- CountryChina
- Language:Chinese
-
Abstract:
Objective Patients with obstructive sleep apnea (OSA) can present with excessive daytime sleepiness (EDS),insomnia,and other symptom subtypes. It remains unclear whether proteomics differs in patients with OSA with EDS and insomnia. Therefore,we examined the serum proteomics of patients with OSA with different clinical subtypes,in order to identify potential biomarkers for the classification of clinical subtypes of OSA,and provide insights into the molecular biological mechanisms underlying different subtypes of the disease. Methods We included six patients with OSA (three with EDS and three with insomnia) at the Second Affiliated Hospital of Air Force Medical University. All the patients underwent overnight polysomnography (PSG) and sleep scale evaluation,followed by blood sample collection on the next morning after PSG. Differentially expressed proteins were selected by label-free quantification,and bioinformatics analysis was performed. Results We identified a subset of 34 proteins that were differentially expressed between OSA with EDS and with insomnia. Compared with the OSA with insomnia group,the OSA with EDS group showed 20 up-regulated and 14 down-regulated serum proteins. The bioinformatics analysis revealed that the main functions of these proteins focused on DNA damage,reactive oxygen species elimination,immune regulation,and inflammatory response,and they were mainly involved in intracellular transport,secretion,and vesicle transport and other biological processes. The differentially expressed proteins were mainly localized in the cytoplasm,which might be secretory proteins. The APRT-AK1 interaction pathway might play an important role in different clinical subtypes of OSA. Conclusion We determined 34 differentially expressed proteins between OSA with EDS and OSA with insomnia,such as significantly up-regulated DDI2 and PRDX6 in the serum of patients with OSA with EDS,which can identify different clinical subtypes of OSA. In addition,the APRT-AK1 interaction pathway might play an important role in different subtypes of OSA.
- Full text:2024061722070109631Serum proteomics of different symptom subtypes of obstructive sleep apnea.pdf
