Characteristics of hippocampal subregion changes in patients with hepatolenticular degeneration and correlation with anxiety and depression
- VernacularTitle:肝豆状核变性患者的海马亚区损伤及其与焦虑、抑郁的相关性研究
- Author:
Hong CHEN
1
;
Wenbin HU
1
Author Information
- Publication Type:Journal Article
- Keywords: Hepatolenticular degeneration; Hippocampal subregion; Anxiety; Depression; Magnetic resonance imaging
- From: Journal of Apoplexy and Nervous Diseases 2023;40(9):798-801
- CountryChina
- Language:Chinese
- Abstract: Objective To analyze the characteristics of changes in hippocampal head，body，and tail subregions of patients with hepatolenticular degeneration （HLD） and their relationship with anxiety and depression. Methods Fortyfive patients with HLD and 30 healthy controls were recruited. T1-weighted magnetic resonance images were acquired. The hippocampus was manually segmented using FreeSurfer 7.2 for volume comparison between the groups. Hamilton Anxiety Scale（HAMA）and Hamilton Depression Scale （HAMD） scores were collected. The relationship between the volumes of hippocampal subregions and HAMA and HAMD scores was analyzed. Results The volumes of the head，body，and tail subregions of both hippocampi of the patients with HLD were all decreased significantly （P<0.05）. In the patients with HLD，the volumes of the hippocampal head （P=0.020），the hippocampal tail （P<0.001），and the whole hippocampus（P=0.001） on the right side were significantly larger than those on the left side，with no significant difference for the hippocampal body （P=0.322）. The HAMA score was negatively correlated with the left hippocampal head volume （r=-0.256，P=0.047）. The HAMD score was negatively correlated with the volumes of the left hippocampal head （r=-0.267，P=0.037），the left hippocampal tail （r=-0.017，P=0.037），the right hippocampal head （r=0.331，P=0.009），and the right hippocampal body （r=-0.265，P=0.039）. Conclusion The volume of hippocampal subregions was decreased in HLD，which was more marked on the left side. The volume of hippocampal subregions was closely correlated with anxiety and depression in patients with HLD.
- Full text:2024061415302039763肝豆状核变性患者的海马亚区损伤及其与焦虑、_抑郁的相关性研究.pdf
