Risk factors for acute pancreatitis in long-term drinking participants: a longitudinal UK Biobank-based study

Jinpeng ZHAO; Yifei MA; Qingyong MA; Zheng WU; Zheng WANG; Xue YANG

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Risk factors for acute pancreatitis in long-term drinking participants: a longitudinal UK Biobank-based study

VernacularTitle:长期饮酒人群发生急性胰腺炎的风险因素分析：一项基于UK Biobank的自然人群研究
Author: Jinpeng ZHAO ¹ ; Yifei MA ¹ ; Qingyong MA ¹ ; Zheng WU ¹ ; Zheng WANG ¹ ; Xue YANG ¹
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1. Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061; Pancreatic Disease Center of Xi’an Jiaotong University, Xi’an 710061, China
Publication Type:Journal Article
Keywords: acute pancreatitis (AP); UK Biobank database; long-term drinking habit; risk factor
From: Journal of Xi'an Jiaotong University(Medical Sciences) 2024;45(2):192-199
CountryChina
Language:Chinese
Abstract: 【Objective】 To examine risk factors for acute pancreatitis (AP) in individuals with chronic alcohol consumption habits. 【Methods】 The study incorporated participants from the initial survey (2006-2010) and subsequent follow-ups (2014+) taken from the UK Biobank database, with the observation period ending on November 30, 2022. During this period, 176 individuals were newly diagnosed with AP, while 59,512 remained unaffected. Vital characteristics of the target population, such as their medical histories, surgical experiences and dietary patterns, were collected during the enrolment phase (2006-2010). The Cox proportional hazard model was employed to ascertain whether these characteristics were potent risk factors for AP. Concurrently, a subgroup from the target population with documented drinking behavior was selected. The multivariate Cox proportional hazard model was utilized to analyze the relationship of the established factors, variances in alcohol consumption, and increased alcohol intake (Δ) with the onset of AP, and whether the additional alcohol intake served as a risk factor. 【Results】 Multivariate analysis revealed that consumption quantity of cooked vegetables inversely correlated with AP risk (HR=0.44, 0.39, 0.42 and 0.41 for one, two, three and four+ tablespoons per day, respectively, as compared to non-consumers). Coffee consumption (2-3 cups per day) also reduced AP risk (HR=0.45 for 2 cups/day; HR=0.39 for 3 cups/day as compared to non-coffee drinkers). However, those with biliary disease without cholecystectomy exhibited a marked increase in AP risk (HR=7.82), which reduced albeit remained elevated for those with biliary disease post-cholecystectomy (HR=2.15). Subgroup analysis showed minimal impact of alcohol intake levels on AP incidence. Yet, increased alcohol consumption (Δ of 1 bottle/week) was linked to a heightened AP risk (HR=1.05, 95% CI:1.02-1.09, P<0.05). 【Conclusion】 Among longstanding alcohol consumers, a diet rich in cooked vegetables and moderate coffee consumption offers protective effects against AP. Conversely, biliary disease (particularly without cholecystectomy) and elevated alcohol intake present considerable risk factors for the development of this condition.