Pregnancy in a case of chronic myeloid leukemia: A case report
- Author:
Maria Clarice G. Ponce
1
;
Grace P. Cayabyab
1
Author Information
- Publication Type:Journal Article
- MeSH: Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Imatinib Mesylate; Postpartum Hemorrhage; Pregnancy
- From: Journal of the Philippine Medical Association 2024;102(2):120-128
- CountryPhilippines
- Language:English
- Abstract: Chronic Myeloid Leukemia, a chronic hematopoietic stem cell disorder, is uncommon among younger age group such as pregnant patients. Due to the rarity of this condition in pregnancy, there are no randomized controlled trials to address the optimal management of this condition. We are presented with a 26 year old patient, who had an unplanned pregnancy in the advanced phase of the disease. Due to the risk to the mother in delaying treatment, she was continued on Imatinib, a tyrosine kinase inhibitor, which is a known fetal teratogen. Her pregnancy was carried to term. The patient delivered via spontaneous vaginal delivery to a live, neonate, with findings of hydrocele and syndactyly on the 4" and 5™ digit of the right foot. Due to the maternal disease progression, she presented with postpartum hemorrhage, in contrast to an augmented procoagulant state among normal pregnancies. Obstetric adjunctive measures, such as intrauterine balloon tamponade and uterine artery ligation, were done. The patient was discharged stable.
- Full text:2024060416474731380Pregnancy in a Case.pdf
