Comorbidity Mechanism of Vertebrobasilar Dolichoectasia and Cerebral Small Vessel Disease Based on Collateral Disease Theory
10.13422/j.cnki.syfjx.20241694
- VernacularTitle:基于络病理论探讨椎基底动脉延长扩张症与脑小血管病的共病机制
- Author:
Yonghui ZHANG
1
;
Daopei ZHANG
2
Author Information
1. The First Clinical Medical School， Henan University of Chinese Medicine，Zhengzhou 450000，China
2. The First Affiliated Hospital of Henan University of Chinese medicine，Zhengzhou 450000，China
- Publication Type:Journal Article
- Keywords:
collateral disease theory;
collaterals;
vertebrobasilar dolichoectasia;
cerebral small vascular disease
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(13):192-201
- CountryChina
- Language:Chinese
-
Abstract:
The comorbidities of vertebrobasilar dolichoectasia（VBD） and cerebral small vessel disease（CSVD） increase the poor prognosis of patients，and elucidating the mechanism underlying their comorbidities helps to explore effective treatment strategies. Therefore，based on the collateral disease theory and combining with the pathogenesis and research progress of traditional Chinese and Western medicine on the understanding of the two，this study proposes that both the disease locations are in the brain collaterals and the pathogenesis is deficiency in foundation and excess in symptoms. The main pathogenesis roots in the deficiency of original Qi and the emptiness of brain collaterals，which corresponds to the dysfunction of endothelial cells and neuro-endocrino-immune networks in modern medicine. The symptoms are cerebral blood stasis，occlusion of cerebral arteries and toxic lesion of cerebral arteries，corresponding to cerebrovascular atherosclerosis，hemodynamic changes，hypoperfusion and toxic metabolites-induced injury of white matter in modern medicine. Based on the collateral disease theory，exploring the common pathogenesis of the VBD and CSVD is expected to facilitate the establishment of TCM treatment scheme including the principles，methods and medicines，and improve the clinical prognosis of patients.
