Analysis of Common Types and Construction Elements of Diabetic Mouse Models
10.12300/j.issn.1674-5817.2023.031
- VernacularTitle:糖尿病小鼠模型的常见种类及其构建要素分析
- Author:
Xue WANG
1
;
Yonghe HU
2
Author Information
1. School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China
2. The General Hospital of Western Theater Command, Chengdu 610083,China
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus;
Animal Model;
Modeling factors;
Mouse
- From:
Laboratory Animal and Comparative Medicine
2023;43(4):415-421
- CountryChina
- Language:Chinese
-
Abstract:
Diabetes mellitus is a disease characterized by absolute or relative lack of insulin, which leads to hyperglycemia, and its high mobidity and complications have a great impact on the lives of patients. Animal models are widely used to study the pathogenesis and treatment of diabetes and its complications. Different types of diabetes, with different pathogenesis and pathognomonic features, have different treatment options. In animal experimental, in addition to considering the genetic factors and physiological characteristics of the animal (such as sex and age), it is also necessary to consider the experimental protocol and various response options, which have a great impact on the experimental data, the reproducibility and stability of the experimental results. Therefore, it is necessary to select suitable animal models for experiments in the study of diabetes. Type 1 diabetes is characterized by absolute insulin deficiency, and existing mouse models of type 1 diabetes include chemically (STZ-induced) induced and spontaneous diabetes model (NOD mice), etc. Type 2 diabetes, characterized by insulin resistance and impaired glucose tolerance, is established in both obese and non-obese animal models, including diet-induced (high-fat diet induced), spontaneous diabetes (including monogenic and polygenic obese mice) models, and genetically modified mouse models. In this review, we discussed the common types of diabetic mouse models and analyzed the elements of their construction, the key factors that should be considered in the selection of diabetic mouse models, and explore the impact of these factors on the research of diabetes.
