Research progress of single-cell RNA sequencing in the immune microenvironment analysis of non-small cell lung cancer
- VernacularTitle:单细胞转录组测序技术在非小细胞肺癌免疫微环境分析中应用的研究进展
- Author:
Wenwen YANG
1
;
Li HE
1
;
Min ZHANG
1
;
Shuo SUN
1
;
Feng WANG
1
;
Minjie MA
2
,
3
;
Biao HAN
2
,
3
Author Information
1. The First Clinical Medical College, Lanzhou University, Lanzhou, 730000, P. R. China
2. Department of Thoracic Surgery, The First Hospital of Lanzhou University, Lanzhou, 730000, P. R. China
3. Gansu Province International Cooperation Base for Research and Application of Key Technology of Thoracic Surgery, The First Hospital of Lanzhou University, Lanzhou, 730000, P. R. China
- Publication Type:Journal Article
- Keywords:
Non-small cell lung cancer;
single-cell RNA sequencing;
tumor immune microenvironment;
immunotherapy;
drug resistance;
review
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2024;31(03):467-472
- CountryChina
- Language:Chinese
-
Abstract:
Non-small cell lung cancer (NSCLC) is one of the most common types of cancer in the world and is an important cause for cancer death. Although the application of immunotherapy in recent years has greatly improved the prognosis of NSCLC, there are still huge challenges in the treatment of NSCLC. The immune microenvironment plays an important role in the process of NSCLC development, infiltration and metastasis, and they can interact and influence each other, forming a vicious circle. Notably, single-cell RNA sequencing enables high-resolution analysis of individual cells and is of great value in revealing cell types, cell evolution trajectories, molecular mechanisms of cell differentiation, and intercellular regulation within the immune microenvironment. Single-cell RNA sequencing is expected to uncover more promising immunotherapies. This article reviews the important researches and latest achievements of single-cell RNA sequencing in the immune microenvironment of NSCLC, and aims to explore the significance of applying single-cell RNA sequencing to analyze the immune microenvironment of NSCLC.
