Progress of the pathogenesis in mantle cell lymphoma
10.3760/cma.j.cn115355-20221025-00678
- VernacularTitle:套细胞淋巴瘤发病机制的研究进展
- Author:
Yanling LI
1
;
Xiaoqi QIN
;
Yanping MA
Author Information
1. 山西医科大学第二临床医学院，太原 030001
- Keywords:
Lymphoma, mantle-cell;
Cyclins;
SOX11 protein;
Epigenomics
- From:
Cancer Research and Clinic
2024;36(1):73-76
- CountryChina
- Language:Chinese
-
Abstract:
Mantle cell lymphoma (MCL) is a rare B cell lymphoma, and its incidence rate is increasing year by year. MCL has the common characteristics of both inert lymphoma and aggressive lymphoma: rapid progress and poor prognosis. The latest research believes that the pathogenesis of MCL is a continuum, and many factors such as cell cycle disorder, SOX11 overexpression, epigenetic aberration play a role in different stages of the disease. This paper mainly reviews the pathogenesis of MCL and new findings of different subtypes from the perspective of molecular genetics,and further analyzes the clinical diversity of MCL. At the same time, the understanding of the pathogenesis of MCL aims to provide potential targets for future treatment of MCL.
