The clinical value of RNA methylation modification as novel tumor molecular diagnostic biomarkers
10.3760/cma.j.cn114452-20231119-00294
- VernacularTitle:RNA甲基化修饰作为肿瘤分子诊断新靶标的价值
- Author:
Cheng WANG
1
;
Junjun WANG
Author Information
1. 南京大学医学院附属金陵医院&东部战区总医院检验科，南京 210002王成现在南京中医药大学附属南京中医院（南京市中医院）医学检验科，南京 210022
- Keywords:
Methylation;
RNA modification;
Neoplasms;
Molecular diagnostic techniques
- From:
Chinese Journal of Laboratory Medicine
2024;47(4):359-370
- CountryChina
- Language:Chinese
-
Abstract:
Malignant tumors have become the main threaten of human health, however, highly sensitive and specific diagnostic biomarkers and effective therapeutic targets are still lacking for most cancers currently. RNA methylation modification has been a cutting-edge hotspot in RNA research area in recent years. The dynamic changes of RNA methylation patterns and levels in tumor tissues, cells as well as patients′ peripheral blood are closely associated with tumor occurrence, development, and prognosis, and have the potential to serve as precise diagnostic markers and effective therapeutic targets for tumors. Even though several challenges such as RNA methylation detection methods, functional mechanism, and the development of therapeutic drugs based on RNA methylation modification are needed to solve, from lab to clinical practice, RNA methylation still display excellent diagnostic and prognosis performance, which can provide new strategies and evidence for precise diagnosis, treatment targets, and drug development of tumors.
