Application of methylation detection in gynecologic tumors
10.3760/cma.j.cn114452-20231025-00231
- VernacularTitle:甲基化检测在妇科肿瘤中的应用
- Author:
Xiaojing CHEN
1
;
Jinghe LANG
;
Lei LI
Author Information
1. 中国医学科学院北京协和医院妇产科 国家妇产疾病临床医学研究中心 中国医学科学院北京协和医院疑难重症及罕见病全国重点实验室，北京100730
- Keywords:
DNA methylation;
Gynecologic tumor;
Screening;
Diagnosis;
Prognosis
- From:
Chinese Journal of Laboratory Medicine
2024;47(4):353-358
- CountryChina
- Language:Chinese
-
Abstract:
The occurrence and development of human malignancies is often accompanied by epigenetic changes, and DNA methylation is one of the most common epigenetic modification. Methylation events are often discovered in the early stage of gynecologic neoplasia. The methylation detection protocol based on liquid biopsy technology has made important progress in the screening and prognosis assessment of gynecologic tumors. The reliability of methylation detection in micro-noninvasive samples from multiple sources is similar to or better than that of traditional protocols and strategies. This article reviews the progress of methylation detection in screening, diagnosis and monitoring of gynecologic tumors, and discusses its value in the present and future diagnosis and treatment of gynecologic tumors.
