Paying attention to the basic research of optic nerve protection and regeneration, and promote its clinical transformation
10.3760/cma.j.cn511434-20231112-00454
- VernacularTitle:重视视神经保护和再生基础研究，推动其向临床转化
- Author:
Yong ZHONG
1
;
Yuezhu LU
Author Information
1. 中国医学科学院北京协和医院眼科 中国医学科学院眼底重点实验室，北京 100730
- Keywords:
Optic neuropathies;
Retinal ganglion cells;
Neuroprotection;
Axonal regeneration;
Stem cells;
Gene therapy;
Editorial
- From:
Chinese Journal of Ocular Fundus Diseases
2023;39(11):883-886
- CountryChina
- Language:Chinese
-
Abstract:
Primary or secondary death of retinal ganglion cells (RGC) is a common outcome in various optic neuropathies, often resulting in severe visual damage. The inherent characteristics of RGC include the continuous upregulation of intracellular growth-inhibitory transcription factors and the downregulation of growth-inducing transcription factors during cell differentiation. Additionally, the external inhibitory microenvironment following RGC damage, including oxidative stress, chronic inflammation, lack of neurotrophic factors, high expression of myelin proteins, and the formation of glial scars, all restrict axonal regeneration. Both intrinsic and extrinsic factors lead to the death of damaged RGC and hinder axonal regeneration. Various neuroprotective agents and methods attempt to promote neuroprotection and axonal regeneration from both intrinsic and extrinsic aspects, and well knowledge of these neuroprotective strategies is of significant importance for promoting the neuroprotective experimental research and facilitating its translation into clinical practice.
