A review of pathogenesis and diagnosis and treatment of vaccine-associated uveitis
10.3760/cma.j.cn511434-20220126-00046
- VernacularTitle:疫苗相关性葡萄膜炎的发病机制、诊断和治疗的研究进展
- Author:
Shuo WU
1
;
Chuan ZHANG
;
Mingwei ZHAO
;
Jing HOU
Author Information
1. 北京大学人民医院眼科 眼视光中心 眼病与视光医学研究所 视网膜脉络膜疾病诊治研究北京市重点实验室 北京大学医学部眼视光学院, 北京 100044
- Keywords:
Vaccine-associated uveitis;
Epidemiology;
Pathogenesis;
Diagnosis and treatment;
Review
- From:
Chinese Journal of Ocular Fundus Diseases
2023;39(9):773-778
- CountryChina
- Language:Chinese
-
Abstract:
Vaccine-associated uveitis (VAU) usually refers to a rare adverse reaction that occurs after vaccination. The clinical manifestations of VAU are most often anterior with mild symptoms and responded promptly to topical corticosteroids. However, more severe forms of posterior and panuveitis may also occur, such as multiple evanescent white dot syndrome, Vogt-Koyanagi-Harada syndrome, and acute posterior multifocal placoid pigment epitheliopathy. The pathogenesis of VAU is still unclear. Currently, it mainly includes vaccine Shoenfeld syndrome, type Ⅲ hypersensitivity reaction caused by immune complex deposition, direct infection with live attenuated vaccine, and molecular mimicry theory. VAU is self-limiting, and most patients heal without treatment. In the future, it is recommended to ask all patients with uveitis about their recent vaccination history in the clinic. For patients with inactivated vaccine or recombinant/subunit vaccination history, the possibility of developing Shoenfeld syndrome should be considered, and the history, signs and symptoms related to autoimmune diseases should be carefully looked for.
