Application of single cell RNA sequencing and spatial transcriptome techniques in common vascular surgery diseases
10.3760/cma.j.cn112434-20230915-00060
- VernacularTitle:单细胞RNA测序和空间转录组技术在常见血管外科疾病中的应用
- Author:
Jing TAO
1
;
Yining YANG
Author Information
1. 新疆维吾尔自治区人民医院心脏及泛血管医学诊疗中心 新疆心脏血管稳态与再生医学研究重点实验室，乌鲁木齐 830001
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2024;40(3):179-185
- CountryChina
- Language:Chinese
-
Abstract:
Vascular surgical diseases refer to systemic vascular diseases in addition to cardiovascular and cerebrovascular diseases. With the development of society and the intensification of population aging, the incidence is increasing year by year. Abdominal aortic aneurysm, aortic dissection, arteriosclerotic occlusive disease, thrombosis and vascular malformation are the most common types of vascular surgical diseases, and it is still unclear of the molecular mechanism of their occurrence and development. Single-cell RNA sequencing(scRNA-seq) combined with Spatial transcriptomics(ST) can identify new or rare cell types, study cell heterogeneity and analyze spatial location information at the single-cell level, which is helpful to explore the level of gene expression and three-dimensional reconstruction, opening up a new way to study the occurrence and development mechanism of common vascular surgical diseases, and has a transformative impact on biomedical research.
