Advances in the study of outer membrane vesicles of gram-negative bacteria in infection and immune regulation
10.3760/cma.j.cn112309-20230417-00098
- VernacularTitle:革兰阴性菌外膜囊泡在感染和免疫调节中的研究进展
- Author:
Yifan LI
1
;
Xinwei LIU
;
Yongwei LI
Author Information
1. 河南中医药大学第二临床医学院，郑州 450046
- Keywords:
Gram-negative bacterium;
Outer membrane vesicle;
Bacterial infection;
Immune regulation
- From:
Chinese Journal of Microbiology and Immunology
2024;44(1):39-43
- CountryChina
- Language:Chinese
-
Abstract:
Outer membrane vesicle (OMV), originating from the outermost membrane of cells, is the extracellular vesicles released by gram-negative bacteria, containing bacterial outer membrane components such as phospholipids, lipopolysaccharide (LPS), outer membrane protein, and bacterial-specific antigens. OMV plays an important role in bacterial physiology and pathogenesis, involving in biofilm formation, horizontal gene transfer, stress and inflammatory responses, and delivery of toxins and other biomolecules. It also plays a vital role in immune regulation and the establishment and maintenance of balanced intestinal microflora. This article provides an overview of the roles of OMV in bacterial infections and immune regulation and the potential application value of OMV in tumor-targeted therapy and new vaccine preparation in the hope to provide new ideas for the prevention and treatment of bacterial infections.
