Progress in the roles of monocytes/macrophages in severe fever with thrombocytopenia syndrome

VernacularTitle:单核/巨噬细胞在发热伴血小板减少综合征中的研究进展
Author: Yanan LIU ¹ ; Xin ZHENG
Author Information

1. 华中科技大学同济医学院附属协和医院感染科，武汉　430022
Keywords: Severe fever with thrombocytopenia syndrome; Monocytes/macrophages; Cytokine storm
From: Chinese Journal of Microbiology and Immunology 2024;44(1):27-33
CountryChina
Language:Chinese
Abstract: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by Dabie bandavirus (DBV), characterized by fever, leukopenia, thrombocytopenia and multiple organ damage. Immune dysfunction induced by DBV is closely associated with the pathogenesis of SFTS. Monocytes/macrophages that are essential in innate immunity are the target cells of DBV, and their interaction with DBV plays an important role in the pathogenesis of SFTS. The review summarizes the progress in the features and mechanisms of monocyte/macrophage-mediated immune responses to DBV infection.