Advances in pathogenesis and drug therapy in hemodialysis patients with pruritus

VernacularTitle:血液透析患者瘙痒症的发病机制及药物治疗进展
Author: Xiaojing TANG ¹ ; Changlin MEI
Author Information

1. 海军军医大学第二附属医院肾脏病科，上海　200003
Keywords: Renal dialysis; Pruritus; Drug therapy; Pathogenesis
From: Chinese Journal of Nephrology 2024;40(1):61-66
CountryChina
Language:Chinese
Abstract: Chronic kidney disease-associated pruritus (CKD-aP), one of the most common and intolerable complications in hemodialysis patients, not only seriously affects patients' quality of life and physical and mental health, but also increases the risk of long-term mortality. The pathogenesis of CKD-aP remains unclear, and immune-inflammatory dysregulation, imbalance of endogenous opioid system, abnormal accumulation of metabolites, xerosis, abnormal histamine level as well as hyperparathyroidism, have all been shown to be associated with pruritus. There is a lack of satisfactory and effective treatment strategies for CKD-aP, which mainly include pharmacological treatment, non-pharmacological treatment and dialysis modality modification. This article mainly reviews recent advances in the pathogenesis and pharmacological treatment of pruritus among hemodialysis patients.