Research progress on IgA-dominant infection-related glomerulonephritis in children
10.3760/cma.j.cn441217-20221130-01150
- VernacularTitle:儿童IgA为主型感染相关性肾小球肾炎的研究进展
- Author:
Ling YU
1
;
Jianhua MAO
Author Information
1. 浙江大学医学院附属儿童医院肾脏内科，国家儿童健康与疾病临床医学研究中心，杭州 310052
- Keywords:
Glomerulonephritis;
Staphylococcal infections;
Child;
IgA-dominant infection-related glomerulonephritis
- From:
Chinese Journal of Nephrology
2023;39(10):793-799
- CountryChina
- Language:Chinese
-
Abstract:
IgA-dominant infection-related glomerulonephritis (IgA-IRGN) is a unique form of infection-associated glomerulonephritis. The main causative organism is staphylococcus. Although IgA-IRGN is rare in children, the prevalence is gradually increasing, and the prognosis is poor in children with immunodeficiency and mucocutaneous barrier dysfunction. The clinical manifestations are varying degrees of hematuria, proteinuria, acute kidney injury and hypocomplementemia. The renal pathology is similar to postinfectious glomerulonephritis, therefore differential diagnosis is challenging. The paper reviews the current research progress of IgA-IRGN to improve the pediatrician's understanding of IgA-IRGN in children and avoid misdiagnosis.
