Clinical effects of Shenxie Zhitong Capsules combined with DONG's Extraordinary Points on patients with knee osteoarthritis of Cold-Dampness Obstruction Pattern
10.3969/j.issn.1001-1528.2024.03.017
- VernacularTitle:参蝎止痛胶囊联合董氏奇穴对寒湿痹阻型膝骨关节炎患者的临床疗效
- Author:
Li LI
1
;
Hong-Sheng ZHAN
Author Information
1. 上海中医药大学附属曙光医院,上海 201203
- Keywords:
Shenxie Zhitong Capsules;
DONG's Extraordinary Points;
knee osteoarthritis;
Cold-Dampness Obstruction
- From:
Chinese Traditional Patent Medicine
2024;46(3):821-825
- CountryChina
- Language:Chinese
-
Abstract:
AIM To explore the clinical effects of Shenxie Zhitong Capsules combined with DONG's Extraordinary Points on patients with knee osteoarthritis of Cold-Dampness Obstruction Pattern.METHODS Eighty patients were randomly assigned into control group(40 cases)for 1-month intervention of DONG's Qi Point,and observation group(40 cases)for 1-month intervention of both Shenxie Zhitong Capsules and DONG's Qi Point.The changes in clinical effects,TCM syndrome scores,LKSS score,WOMAC score,NRS score,AIMS2-SF score,sIL-4R,TNF-α,HMGBl,TLR-4,BALP,BGP and β-CTX were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P＜0.05).After the treatment,the two groups displayed decreased TCM syndrome scores,WOMAC score,NRS score,sIL-4R,TNF-α,HMGBl,TLR-4,β-CTX(P＜0.05),and increased LKSS score,AIMS2-SF score,BALP,BGP(P＜0.05),especially for the observation group(P＜0.05).CONCLUSION For the patients of Cold-Dampness Obstruction Pattern,Shenxie Zhitong Capsules combined with DONG's Extraordinary Points can inhibit body inflammatory responses,improve bone metabolism,and relieve knee pain and clinical symptoms.
