Clinical effects of Bufei Huatan Dingchuan Decoction on patients with acute exacerbation of chronic obstructive pulmonary disease of Lung-Kidney Deficiency Pattern
10.3969/j.issn.1001-1528.2024.03.016
- VernacularTitle:补肺化痰定喘汤对肺肾亏虚型慢性阻塞性肺疾病急性加重期患者的临床疗效
- Author:
Hua YANG
1
;
Hong-Hao WU
;
Wei LU
;
Yu-Mei WANG
;
Guo-Qing LI
;
Hui ZHU
Author Information
1. 赣州市中医院,江西 赣州 341000
- Keywords:
Bufei Huatan Dingchuan Decoction;
conventional treatment;
acute exacerbation of chronic obstructive pulmonary disease;
Lung-Kidney Deficiency
- From:
Chinese Traditional Patent Medicine
2024;46(3):817-821
- CountryChina
- Language:Chinese
-
Abstract:
AIM To explore the clinical effects of Bufei Huatan Dingchuan Decoction on patients with acute exacerbation of chronic obstructive pulmonary disease of Lung-Kidney Deficiency Pattern.METHODS One hundred and thirty-eight patients were randomly assigned into control group(69 cases)for 4-week intervention of conventional treatment,and observation group(69 cases)for 4-week intervention of both Bufei Huatan Dingchuan Decoction and conventional treatment.The changes in clinical effects,MMP-2,HIF-1α,TGF-β1,Gal-3,IL-6,pulmonary function indices(FVC,PEF,FEV1/FVC),6-minute walk distance,CAT score and TCM syndrome score were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P＜0.05).After the treatment,the two groups displayed decreased MMP-2,HIF-1α,TGF-β1,IL-6,Gal-3,CAT score,TCM syndrome score(P＜0.05),increased function indices(except for FVC)(P＜0.05),and prolonged 6-minute walk distance(P＜0.05),especially for the observation group(P＜0.05).CONCLUSION For the patients of Lung-Kidney Deficiency Pattern,Bufei Huatan Dingchuan Decoction can alleviate inflammatory reactions,improve body hypoxia state,regulate lung functions,prevent airway tissue remodeling,promote disease recovery,and enhance clinical effects.
