Chemical constituents from stems and leaves of Lonicera confusa and their anti-inflammatory activities
10.3969/j.issn.1001-1528.2024.02.022
- VernacularTitle:山银花茎叶化学成分及其抗炎活性研究
- Author:
Xiao-Hua JIANG
1
;
Yu-Lu WEI
;
Jun BAI
;
Xiao-Jie YAN
;
Dian-Peng LI
;
Feng-Lai LU
Author Information
1. 广西植物功能物质与资源持续利用重点实验, 广西壮族自治区中国科学院广西植物研究所, 广西桂林 541006
- Keywords:
stems and leaves of Lonicera confusa;
iridoid glycosides;
flavonoid;
anti-inflammatory activities
- From:
Chinese Traditional Patent Medicine
2024;46(2):484-489
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the chemical constituents and their anti-inflammatory activities of stems and leaves of Lonicera confusa DC.METHODS The 80%methanol extract from stems and leaves of L.confusa DC was isolated and purified by Diaion HP20SS,Sephadex LH-20,HSCCC and preparative HPLC,then the structures of obtained compounds were identified by physicochemical properties and spectral data.Their anti-inflammatory activities were evaluated by measuring NO production of LPS-stimulated RAW264.7 cells in vitro.RESULTS Thirteen compounds were isolated and identified as benzyl alcohol-O-β-D-glucopyranosyl-(1 →6)-β-D-glucopyranoside(1),sweroside(2),epi-vogeloside(3),vogeloside(4),secologanoside(5),secoxyloganin(6),secologanin dimethyl acetal(7),methyl chlorogenate(8),apigenin-7-O-β-D-glucopyranoside(9),luteolin-7-O-β-D-glucopyranoside(10),rhoifolin(11),luteolin-7-O-α-L-arabinopyranosyl(1→6)-β-D-glucopyranoside(12),and lonicerin(13).Compounds 2-8,11-13 inhibited the NO production of LPS-induced cells.CONCLUSION Compound 1 is first isolated from family Lonicera,compounds 3,5,7,9,11,and 12 are obtained from the stems and leaves of this plant for the first time.Compounds 2-8,11-13 exhibited anti-inflammatory activities.
