Clinical effects of Jingu Xiaotong Powder combined with platelet-rich plasma on patients with knee osteoarthritis
10.3969/j.issn.1001-1528.2024.02.018
- VernacularTitle:筋骨消痛散联合富血小板血浆对膝关节骨性关节炎患者的临床疗效
- Author:
Rui-Xin ZHANG
1
;
Qin-Jian WANG
;
Xing-Fu JIANG
;
Bo-Bo LI
;
Dong-Kang XU
Author Information
1. 河南省中医院/河南中医药大学第二附属医院骨病二科, 河南 郑州 450002
- Keywords:
Jingu Xiaotong Powder;
platelet-rich plasma;
knee osteoarthritis
- From:
Chinese Traditional Patent Medicine
2024;46(2):465-469
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the clinical effects of Jingu Xiaotong Powder combined with platelet-rich plasma on patients with knee osteoarthritis.METHODS Ninety-six patients were randomly assigned into control group(48 cases)for 8-week administration of platelet-rich plasma,and observation group(48 cases)for 8-week administration of both Jingu Xiaotong Powder and platelet-rich plasma.The changes in clinical effects,IL-17,SDF-1,TLR4,GSH-Px,NO,ox-LDL,WOMAC scores,TCM syndrome score,AIM2-SF score were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P<0.05).After the treatment,the two groups displayed decreased IL-17,SDF-1,TLR4,NO,ox-LDL,WOMAC scores,TCM syndrome score(P<0.05),and increased GSH-Px,AIM2-SF score(P<0.05),especially for the observation group(P<0.05).CONCLUSION For the patients with knee osteoarthritis,Jingu Xiaotong Powder combined with platelet-rich plasma can reduce IL-17,SDF-1,TLR4 levels,inhibit body inflammation,improve oxidative stress indices,alleviate pain,and enhance clinical efficacy and life quality.
