Gut microbiota and immune mechanism of type 1 diabetes mellitus

VernacularTitle:肠道菌群与1型糖尿病免疫机制的研究进展
Author: Bing ZHANG ¹ ; Yuanyuan FANG ; Yuying WANG ; Huijuan YUAN
Author Information

1. 郑州大学人民医院（河南省人民医院）内分泌与代谢病科，郑州　450003
Keywords: Diabetes mellitus, type 1; Gut microbiota; Immune mechanism
From: Chinese Journal of Endocrinology and Metabolism 2024;40(3):270-274
CountryChina
Language:Chinese
Abstract: Type 1 diabetes mellitus is a T-cell-mediated autoimmune disease that commonly affects adolescents, characterized by progressive destruction of pancreatic β-cells, absolute insulin deficiency, and hyperglycemia. The pathogenesis of type 1 diabetes mellitus is complex and is believed to be mainly associated with immunity, environment, and genetics. There is increasing evidence that gut microbiota is closely related to the occurrence of type 1 diabetes mellitus. This article focuses on the immune mechanisms and roles of gut microbiota and its derivatives in the development of type 1 diabetes mellitus from the perspectives of innate and adaptive immunity. Additionally, it introduces therapeutic approaches targeting gut microbiota for the treatment of type 1 diabetes mellitus.