Serum TSH levels in women aged 40 and above : association with lifespan and 10-year mortality
10.3760/cma.j.cn311282-20230827-00043
- VernacularTitle:40岁及以上女性人群血清TSH水平与寿命及10年死亡的相关性研究
- Author:
Ping XU
1
;
Nianchun PENG
;
Miao ZHANG
;
Ying HU
;
Rui WANG
;
Juan HE
;
Qiao ZHANG
;
Lixin SHI
Author Information
1. 贵州医科大学附属医院内分泌代谢病科，贵阳 550004
- Keywords:
Thyroid-stimulating hormone;
All-cause mortality;
Women;
Middle-aged and elderly;
Lifespan
- From:
Chinese Journal of Endocrinology and Metabolism
2024;40(2):132-138
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between thyroid-stimulating hormone(TSH) levels and 10-year mortality in women aged 40 years and older.Methods:Residents aged 40 and over in urban areas of Guiyang City who participated in the " Epidemiological Study of Cancer Risk in Patients with Type 2 Diabetes in China(REACTION)" were followed up in 2011. Finally, 5 614 people were enrolled, and the baseline general information, physical examination and TSH detection were carried out. The average follow-up was(9.77±1.55) years, and the treatment and death of thyroid-related diseases were recorded. The Cox proportional hazards model was used to analyze the relationship between TSH level and 10-year mortality in middle-aged and elderly women, and plotting survival time curves(Kaplan-Meier curves) to study the association between elevated TSH levels and lifespan in subjects under 65 years old. Results:The multivariate Cox proportional hazards model showed that compared with the normal group, after multivariate adjustment, the risk of death in the TSH increased group was decreased( HR=0.644, 95% CI 0.478-0.868, P<0.05); after stratifying the elevated TSH group, the risk of death was decreased in the slightly elevated TSH group( HR=0.566, 95% CI 0.405-0.791, P<0.001); the elevated TSH group was further stratified by age. In the group under 65 years old, compared to the normal group, the mildly elevated group showed a reduced risk of mortality( HR=0.429, 95% CI 0.245-0.751, P=0.003). In the group aged 65 and above, there were no statistically significant differences in mortality risk between the mildly elevated group, severely elevated group, and the normal group( P>0.05). In the group under 65 years old, the K-M curve indicated that the survival rate of the mildly elevated TSH group was significantly higher than that of the normal group( χ2=11.931, P=0.003), the difference was statistically significant. Conclusion:Mildly elevated TSH levels in women aged 40-65 years are associated with a reduced risk of all-cause death and longer lifespan.
