Advances in the research of thyroid organoid
10.3760/cma.j.cn311282-20230627-00287
- VernacularTitle:甲状腺类器官研究进展
- Author:
Jinyu YAO
1
;
Qingmiao LU
;
Yibing LU
Author Information
1. 南京医科大学第二附属医院内分泌代谢科 210011
- Keywords:
Organoids;
Thyroid gland;
Three-dimensional culture
- From:
Chinese Journal of Endocrinology and Metabolism
2024;40(1):73-76
- CountryChina
- Language:Chinese
-
Abstract:
As cell aggregates in three-dimensional culture derived from primary tissues or stem cells, organoids possess the ability to self-organize into organotypic structures, mimic the cellular microenvironment, and represent tissue physiology. The thyroid′s follicular tissue plays a crucial role in thyroid hormone biosynthesis. Despite prolonged in vitro expansion of thyroid follicles from adult tissues and pluripotent stem cells have been expanded for a long time, the development of thyroid organoid technology still encounters numerous challenges. Establishing a comprehensive thyroid organoid that closely mimics the human body′s actual conditions remains a research challenge. This article reviews the development process of thyroid, the related applications of existing thyroid organoid models and the methods employed in the construction.
