Pharmacodynamics of ropivacaine for ultrasound-guided pericapsular nerve group block in hip surgery
10.3760/cma.j.cn131073.20231008.01218
- VernacularTitle:罗哌卡因用于超声引导髋关节囊周神经阻滞的药效学
- Author:
Yongquan ZHU
1
;
Wenxin ZHANG
;
Shuping HUO
Author Information
1. 河北医科大学第三医院麻醉科，石家庄 050051
- Keywords:
Dose-response relationship, drug;
Amides;
Nerve block;
Joint capsule;
Fascia;
Ultrasonography
- From:
Chinese Journal of Anesthesiology
2023;43(12):1499-1502
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the pharmacodynamics of ropivacaine for ultrasound-guided pericapsular nerve group (PENG) block in hip surgery.Methods:American Society of Anesthesiologists Physical Status classification Ⅰ or Ⅱ patients of either sex with hip trauma (femoral neck or trochanteric fracture), aged 18-64 yr, with body mass index of 18-30 kg/m 2, scheduled for elective hip surgery under general anesthesia, with VAS score>4 points at 15 degrees of hip flexion, were selected. PENG block was performed at 30 min before anesthesia, and 0.375% ropivacaine was injected with an initial dose of 15 ml and the successive volume gradient of 1.2 ml after successful localization. VAS score was assessed at 30 min after injection. When the VAS score was 3, the block was considered effective, a lower volume gradient was given in the next patient, otherwise a higher volume gradient was given in the next patient, which was repeated until 7 up-and-down cross waveforms were obtained. Probit analysis was used to calculate the median effective volume (EV 50) and 95% effective volume (EV 95) and 95% confidence interval ( CI) of 0.375% ropivacaine for PENG block. Results:The EV 50 (95% CI) of 0.375% ropivacaine for PENG block was 11.36 ml (9.41-12.64 ml), and the EV 95 (95% CI) of 0.375% ropivacaine for PENG block was 14.19 ml (95% CI 12.80-25.07 ml). Conclusions:The EV 50 of 0.375% ropivacaine is 11.36 ml when used for ultrasound-guided PENG block in hip surgery.
