Effects of different doses of esketamine on patient status index under propofol-remifentanil-based anesthesia
10.3760/cma.j.cn131073.20230625.01217
- VernacularTitle:复合丙泊酚-瑞芬太尼麻醉时不同剂量艾司氯胺酮对患者状态指数的影响
- Author:
Lijuan ZHU
1
;
Xing MAO
;
Yonghao YU
Author Information
1. 天津医科大学总医院空港医院麻醉科，天津 300000
- Keywords:
Ketamine;
Propofol;
Remifentanil;
Patient state index
- From:
Chinese Journal of Anesthesiology
2023;43(12):1495-1498
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effects of different doses of esketamine on patient status index (PSI) under propofol-remifentanil-based anesthesia.Methods:One hundred patients of either sex, aged 22-62 yr, with body mass index of 18-28 kg/m 2, of American Society of Anesthesiologists Physical Status classificationⅠ or Ⅱ, were divided into 5 groups ( n=20 each) using a random number table method: normal saline group (group NS) and different doses of esketamine groups (E1-4 groups). Anesthesia was induced and maintained by target-controlled intravenous infusion of propofol and remifentanil.When the depth of anesthesia was stable (PSI value 25-50 ) for 5 min after tracheal intubation and no surgical stimulation was given, esketamine 0.1, 0.2, 0.3 and 0.4 mg/kg were intravenously injected over 60 s in E1-4 groups respectively, and normal saline 10 ml was intravenously injected in NS group. PSI values were recorded at 1-min intervals (1-15 min, T 1-T 15) immediately before anesthesia induction (T 0) and after esketamine administration. PSI values>50, bradycardia and hypotension were recorded during the test. Results:Compared with NS group, no significant change was found in PSI values at each time point in E1 group ( P>0.05), PSI value was significantly increased at T 5-T 10 in E2 group, PSI value was increased at T 5-T 12 in E3 group, PSI value was increased at T 1-T 15 in E4 group, and the incidence of PSI value >50 was increased in E2, E3 and E4 groups ( P<0.05). The incidence of PSI value >50 was significantly higher in E3 and E4 groups than in E2 group ( P<0.05). There was no significant difference in the incidence of PSI value >50 between group E3 and group E4 ( P>0.05). There was no significant difference in the incidence of hypotension and bradycardia among the five groups ( P>0.05). Conclusions:Esketamine ≥ 0.2 mg/kg increases the patient′s PSI value when combined with propofol-remifentanil anesthesia.
