Effect of small-dose naloxone on development of nausea and vomiting during postoperative analgesia with opioid drugs: a meta-analysis
10.3760/cma.j.cn131073.20230823.01209
- VernacularTitle:小剂量纳洛酮对患者阿片类药物术后镇痛时恶心呕吐发生的影响：meta分析
- Author:
Xu YANG
1
;
Xiaodong WANG
;
Caixia WANG
;
Yumei DING
;
Yi QIU
Author Information
1. 内蒙古医科大学第二附属医院麻醉手术中心，呼和浩特 010030
- Keywords:
Naloxone;
Analgesics, opioid;
Analgesia;
Postoperative Nausea and Vomiting;
Meta-analysis
- From:
Chinese Journal of Anesthesiology
2023;43(12):1459-1464
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To systematically review and evaluate the effect of small-dose naloxone on the development of nausea and vomiting during postoperative analgesia with opioid drugs in patients.Methods:Electronic Databases including Pubmed, Embase, Cochrane, Web of Science, China National Knowledge Infrastructure, Wanfang Data, China Biomedical Literature Database, and China Science and Technology Journal Database databases were searched from inception to May 2023 for randomized controlled trials involving the effect of small-dose naloxone on the development of adverse effects during postoperative analgesia with opioids. All randomized controlled trials enrolled included naloxone group and control group, the primary outcome was the incidence of postoperative nausea and vomiting, and the secondary outcome was postoperative VAS. Meta-analysis was performed using Stata 16.0 software.Results:Seven randomized controlled trials involving 542 patients were finally included in this meta-analysis. Compared with control group, the incidence of nausea and vomiting during postoperative analgesia was significantly decreased in naloxone group ( P<0.05), and no significant change was found in postoperative VAS scores ( P>0.05). Conclusions:Small-dose naloxone can reduce the development of nausea and vomiting during postoperative analgesia with opioid drugs.
