Exogenous insulin antibody syndrome in an elderly patient: a case report and literature review
10.3760/cma.j.issn.0254-9026.2023.12.009
- VernacularTitle:老年外源性胰岛素抗体综合征一例并文献复习
- Author:
Xinyuan FENG
1
;
Lina ZHANG
;
Lixin GUO
;
Qi PAN
Author Information
1. 北京协和医学院研究生院，中国医学科学院，北京医院内分泌科，国家老年医学中心，中国医学科学院老年医学研究院，北京 100730
- Keywords:
Insulin antibodies;
Hypoglycemia;
Diabetes, type 2;
Exogenous insulin antibody syndrome
- From:
Chinese Journal of Geriatrics
2023;42(12):1442-1446
- CountryChina
- Language:Chinese
-
Abstract:
For diabetes patients, especially elderly diabetes patients, insulin is widely used as an important treatment to control hyperglycemia.However, since a high percentage of elderly diabetes patients use high doses of insulin, it is common to incur issues such as increased insulin resistance and inappropriate treatment.Exogenous insulin-induced autoantibody production is associated with severe insulin resistance and refractory hyperglycemia and hypoglycemia and is referred to as exogenous insulin antibody syndrome.With hypoglycemia, high insulin levels may be inconsistent with C-peptide levels.Increasing the dose of insulin to control blood glucose may be counterproductive.It is necessary to quickly and accurately make a diagnosis and make personalized adjustments to the glucose-lowering regimen to avoid serious consequences.
