The effect of extracellular vesicles on the regulation of mitochondrial quality control and inflammation in frailty and sarcopenia in older people
10.3760/cma.j.issn.0254-9026.2023.10.022
- VernacularTitle:细胞外囊泡在衰弱肌少症患者中对线粒体质量控制与炎症的调节效应
- Author:
Lingxiao WANG
1
;
Fang YAN
;
Lihua ZHOU
Author Information
1. 成都市第五人民医院（成都中医药大学附属第五人民医院/第二临床医学院）老年医学科，成都市老年疾病研究所，成都 611130
- Keywords:
Frailty;
Sarcopenia;
Extracellular vesicles;
Exosomes;
Mitochondrial dysfunction
- From:
Chinese Journal of Geriatrics
2023;42(10):1259-1264
- CountryChina
- Language:Chinese
-
Abstract:
The pathogenesis of frailty and sarcopenia(PF&S)is multifaceted and complex, ranging from local muscle-specific processes(mitochondrial quality control disorders in skeletal muscle cells)to systemic changes(chronic inflammation).However, the important molecular factors linking these mechanisms are not well understood.Recent studies have shown that extracellular vesicles(EVs)play an important role in the aging microenvironment and age-related diseases.This article reviewed the characteristics and potential connections of mitochondrial quality control(MQC)disorders and chronic inflammation in the context of PF&S, focusing on the potential role of EVs in the interaction between the two types of conditions, in order to provide insights for future research.
