Expression and diagnostic value of serum miR-483-3p in patients with essential hypertension
10.3969/j.issn.1009-0126.2024.01.005
- VernacularTitle:微小RNA-483-3p在原发性高血压患者血清中的水平及诊断价值
- Author:
Chao WANG
1
;
Xiaojun CHEN
;
Fang WANG
Author Information
1. 572000 三亚中心医院(海南省第三人民医院)药学部
- Keywords:
circulating microRNA;
essential hypertension;
diagnosis;
root cause analysis;
miR-483-3p
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2024;26(1):17-20
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the level and diagnostic value of microRNA(miR)-483-3p in the serum of patients with essential hypertension(EH).Methods A total of 180 EH patients ad-mitted in Department of Cardiology of Sanya Central Hospital from January 2021 to March 2023 were enrolled as the study group,and another 160 healthy volunteers matched in general clinical data and taking physical examination during the same period were subjected as the control group.RT-qPCR was used to detect miR-483-3p levels in the sera of the 2 groups.Results The levels of TC,TG,LDL-C,SBP,and DBP were significantly higher(P＜0.01),so was the serum miR-483-3p level(2.15±0.57 vs 1.00±0.05,P＜0.01)in the study group than the control group.The serum miR-483-3p level was in an obvious upward trend in the patients with hypertension of grades 1,2,and 3(1.44±0.45 vs 1.79±0.58 vs 3.35±0.64,P＜0.05).The level was positively correlated with hypertension grade in the study group(r=0.745,P=0.000),and the levels of TC,TG,LDL-C,SBP and DBP(P＜0.01).miR-483-3p,TC,LDL-C,SBP and DBP were independent influencing factors for EH(P＜0.05,P＜0.01).The AUC value of serum miR-483-3p level for predicting EH was 0.923(95％CI:0.890-0.949).Conclusion Serum miR-483-3p level is increasing with severi-ty of EH,and has a high diagnostic value for the disease.
