Efficacy of sacubitril/valsartan combined with sodium nitroprusside for acute heart failure in elderly patients
10.3969/j.issn.1009-0126.2023.12.013
- VernacularTitle:沙库巴曲缬沙坦联合硝普钠治疗对老年急性心力衰竭患者的疗效观察
- Author:
Jinling XU
1
;
Wei WANG
;
Kun ZHANG
;
Lijun CUI
Author Information
1. 300457 天津医科大学心血管病临床学院泰达国际心血管病医院介入中心
- Keywords:
heart failure;
nitroprusside;
valsartan;
comparative effectiveness research
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2023;25(12):1285-1288
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy of sacubitril/valsartan combined with sodium ni-troprusside in treatment of acute heart failure(AHF)in elderly patients.Methods A total of 280 elderly AHF patients admitted in our hospital from June 2020 to June 2021 were enrolled and ran-domly divided into control group(143 cases,sodium nitroprusside treatment)and observation group(137 cases,sodium nitroprusside+sacubitril/valsartan).Their indicators in hemodynamics,cardiac function and vascular endothelial function,neurohormone factors and clinical total effec-tive rate were compared between 2 groups.Results After treatment,the observation group ob-tained significantly lower central venous pressure,mean arterial pressure,pulmonary vascular re-sistance,peripheral vascular resistance,left ventricular end-diastolic diameter,left ventricular end-systolic diameter,left ventricular end systolic volume,and levels of endothelin 1,N-terminal-type B natriuretic peptide precursor and noradrenaline,but higher LVEF and NO levels than the con-trol group(P＜0.01).The total effective rate was statistically higher(97.08％vs 86.71％,P=0.002),but the incidence of adverse reactions was notably lower(11.68％vs 20.98％,P=0.036)in the observation group than the control group.Conclusion The combined treatment reduces he-modynamic indicators and neurohormone factors,and regulates the cardiac function and vascular endothelial function in elderly AHF patients.It is superior to sodium nitroprusside monotherapy with better total effectiveness but lower incidence of adverse reactions.
