Research progress of surface coating modification techniques for magnesium-based implants in orthopaedics
10.3760/cma.j.cn121113-20230823-00119
- VernacularTitle:骨科镁基植入物表面涂层改性技术的研究进展
- Author:
Botao LIU
1
;
Xiaodong HU
;
Mingming HAO
;
Zhaoxiang PENG
Author Information
1. 宁波大学附属李惠利医院关节与运动医学科，宁波 315040
- Keywords:
Magnesium;
Prostheses and implants;
Surface modification;
Coatings
- From:
Chinese Journal of Orthopaedics
2024;44(1):58-64
- CountryChina
- Language:Chinese
-
Abstract:
Magnesium and its alloys have been widely studied in the field of orthopaedics for their desirable mechanical properties, biodegradability and biocompatibility. However, the rapid degradation rate of magnesium and its alloys cannot match the healing process of bone itself, and may adversely affect the adhesion, growth and differentiation of surrounding cells, resulting in early loosening of implants, thus limiting their wide clinical application. Surface coating modification is a feasible and promising anti-corrosion solution to solve the problem of uncontrollable corrosion rate of magnesium implants. The surface coating modification technology can optimize the integration of the bone-implant interface by improving the bone induction ability of the implant surface (such as the bio-mimetic coating based on phosphate ceramics) or improving the corrosion resistance (such as the micro-arc oxidation coating with wear resistance and corrosion resistance, and the phytic acid coating with self-healing potential). While optimizing the degradation rate of magnesium implant, it can also realize multiple functions such as promoting osseointegration, drug delivery and photothermal therapy through composite component modification. In this paper, the advantages and disadvantages of different coating modification method on the surface of orthopaedic magnesium implants are comprehensively illustrated, and the key technologies in each preparation process are summarized and the composite modification methods are further discussed, so as to provide references for the preparation of multifunctional magnesium implants that meet the requirements of orthopaedic applications.
