Clinical research progress of boron neutron capture therapy for head and neck cancer
10.3760/cma.j.cn113030-20221129-00402
- VernacularTitle:硼中子俘获疗法治疗头颈部恶性肿瘤的临床研究进展
- Author:
Yanping WU
1
;
Fengxia LUO
;
Yuemin LI
Author Information
1. 解放军总医院第八医学中心放射治疗科，北京 100091
- Keywords:
Head and neck neoplasms;
Boron neutron capture therapy;
Clinical trials
- From:
Chinese Journal of Radiation Oncology
2024;33(1):62-66
- CountryChina
- Language:Chinese
-
Abstract:
Boron neutron capture therapy is a method based on 10B (n,α) 7Li reaction to achieve malignancy treatment. Upon entry into the human body, the 10B compound carrier can selectively enriched in tumor cells and reacts with external irradiation neutrons. Because 7Li (4 μm) and α particles (7 μm) will be deposited in a cell magnitude (10 μm), the purpose of directional local killing of tumor cells and causing less harm to normal tissue can be achieved successfully. So far, boron neutron capture therapy has been clinically studied in a variety of malignant diseases, including glioblastoma multiforme, meningeoma, head and neck cancer, lung cancer, etc. In this article, the clinical research progress of boron neutron capture treatment in head and neck carcinomas was mainly introduced.
