Visual transient elastography combined with liver steatosis analysis for assessing liver function injury after ablation
10.3760/cma.j.cn131148-20231026-00185
- VernacularTitle:可视化瞬时弹性成像联合脂肪变定量分析评估消融术后肝功能损伤
- Author:
Xitian LIANG
1
;
Wei YANG
;
Yuxin CHEN
;
Yu CHEN
;
Xue HAN
;
Wen CHENG
Author Information
1. 哈尔滨医科大学附属肿瘤医院超声医学科，哈尔滨 150081
- Keywords:
Visual transient elastography;
Liver steatosis analysis;
Hepatocellular carcinoma;
Hepatitis B;
Ablation therapy;
Liver function injury
- From:
Chinese Journal of Ultrasonography
2024;33(3):209-215
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the value of a novel technique called visual transient elastography (ViTE) and liver steatosis analysis (LiSA) in assessing liver function injury in hepatitis B virus-related hepatocellular carcinoma (HBV-related HCC) patients after ablation therapy.Methods:A total of 129 HBV-related HCC patients in Harbin Medical University Cancer Hospital from January 2022 to August 2023 were retrospectively analyzed.ViTE and LiSA examinations were applied to record the liver stiffness E value and LiSA value before ablation. An albumin-bilirubin (ALBI) score was constructed using laboratory indicators. Spearman correlation analysis was used to assess the correlation between E value, LiSA value and ALBI score, body mass index (BMI). According to the change of ALBI grade in perioperative period, the patients could be divided into two groups: liver function unchanged group and liver function injury group. Univariate and multivariate statistical methods were used to analyze related factors affecting changes in liver function after ablation, followed by establishing a predictive model.Results:Spearman analysis showed a strong positive correlation between E value and ALBI score ( rs=0.686, P<0.001), and LiSA value was weakly positively correlated with BMI ( rs=0.338, P<0.001). There were no significant correlations between E value and BMI, LiSA value and ALBI score (all P>0.05). Univariate analysis showed that differences of age, BMI, ablation parameters, E value, and LiSA value in the two groups were statistically significant (all P<0.05). Multivariate analysis showed that E value, LiSA value, and ablation time were independent predictors of hepatic dysfunction after ablation (all P<0.05). AUC was 0.892 indicating high accuracy in the predictive model based on above indicators. Conclusions:Under the real-time ultrasound guidance, a non-invasive liver function injury prediction model based on ViTE and LiSA technology can offer personalized predictions for ablative perioperative changes in liver function among HBV-related HCC patients.
