Research concerning traditional Chinese medicine into correlation between mitogen-activated protein kinases and osteoporosis
10.3760/cma.j.cn115530-20230911-00101
- VernacularTitle:基于促分裂素原活化蛋白激酶通路影响骨代谢相关中药的研究进展
- Author:
Wanxin LIU
1
;
Qiugen WANG
;
Dong ZHANG
Author Information
1. 上海中医药大学附属岳阳中西医结合医院，上海 200437
- Keywords:
Mitogen-activated protein kinases;
Osteoporosis;
MAP Kinase signaling system;
Traditional Chinese medicine
- From:
Chinese Journal of Orthopaedic Trauma
2023;25(11):1008-1012
- CountryChina
- Language:Chinese
-
Abstract:
Osteoporosis (OP) is a systemic bone metabolic disease when bone resorption becomes greater than bone formation, resulting in bone mass loss and poor bone structure. The disability or fatality caused by its complications has become a global public problem. As mitogen-activated protein kinases (MAPK) are important molecules that maintain and regulate cellular energy balance, they are closely related to bone metabolism. In clinical practice, traditional Chinese medicine has demonstrated obvious advantages in prevention and treatment of OP. However, there has not been enough comprehensive or systematic summary of the researches into the regulatory mechanisms of this signaling pathway in the treatment of OP by traditional Chinese medicine. Therefore, this paper expounds on the effects of single traditional Chinese herb and compound traditional Chinese herbs on the regulatory mechanisms of MAPK signaling pathway in bone metabolism so that a theoretical basis can be provided for future basic and clinical researches in the prevention and treatment of OP.
