Immunoregulatory effects of human umbilical cord mesenchymal stem cells in the inflammatory response after spinal cord injury: a review
10.3760/cma.j.cn501098-20230613-00342
- VernacularTitle:人脐带间充质干细胞在脊髓损伤后炎症反应中免疫调节作用的研究进展
- Author:
Heng WANG
1
;
Cheng CHEN
;
Yang LU
;
Yulin ZHAO
;
Xiaoqing CHEN
Author Information
1. 南通大学附属医院脊柱外科，南通 226001
- Keywords:
Mesenchymal stem cells;
Exosomes;
Immunomodulation;
Inflammation;
Spinal cord injury
- From:
Chinese Journal of Trauma
2023;39(11):1037-1045
- CountryChina
- Language:Chinese
-
Abstract:
Spinal cord injury is a serious injury of the central nervous system that can result in partial or complete loss of sensory and motor function. The clinical treatments for spinal cord injury include laminotomy and decompression and high-dose intravenous methylprednisolone, etc. Both treatments fail to stimulate neuronal and axonal regeneration and are associated with serious complications. Human umbilical cord mesenchymal stem cells (HUC-MSCs) have advantages of high activity, low immunogenicity and strong immunomodulatory effects, etc, which can target immune cells and immune organs, improve the local microenvironment in the injured area and create favorable conditions for spinal cord injury repair. Nonetheless, the immunomodulatory effects of HUC-MSCs transplantation following spinal cord injury remains under-recognized. For this, the authors reviewed the advances of researches on the immunomodulatory effects of HUC-MSCs in the inflammatory response after spinal cord injury so as to provide a reference for the selection of therapeutic targets for spinal cord injury.
