MicroRNA in acute kidney injury due to sepsis
10.3760/cma.j.cn101721-20221208-000579
- VernacularTitle:微小RNA在脓毒症所致急性肾损伤中的应用
- Author:
Hongxing DONG
1
;
Weidong WU
Author Information
1. 山西医科大学第三医院 山西白求恩医院重症医学科，太原 030032
- Keywords:
Septisis;
Acute kidney injury;
MiRNA;
Diagnosis;
Prognosis;
Treatment
- From:
Clinical Medicine of China
2023;39(5):385-388
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is a life-threatening clinical syndrome characterized by organ dysfunction caused by dysregulation of the body's immune response to infection, and is the primary cause of acute kidney injury in critically ill patients. Sepsis induced AKI (S-AKI) is a common clinical critical illness with a high mortality rate and is closely associated with the clinical outcome of critically ill patients. At present, the clinical diagnosis of AKI is still based on the traditional indicators such as serum creatinine and urine output, but it is easily interfered by age, gender, drugs and other factors, and cannot accurately and sensitively reflect the renal damage of patients, so that some AKI patients lose the best time for treatment. Therefore, some biomarkers with strong sensitivity and high specificity are urgently needed in the clinic to help the diagnosis of AKI, so as to take active therapeutic measures to alleviate the prognosis of AKI.Numerous studies have shown that microRNAs (miRNAs) are involved in the development of S-AKI. Therefore, miRNAs can not only be early diagnostic markers of S-AKI, but also have important potential value for the treatment and prognosis of S-AKI. In this paper, we review the potential value of miRNA for the diagnosis, prognosis and treatment of S-AKI.
