Effects of low-frequency rTMS combined with paroxetine on clinical symptoms and social abilities in patients with panic disorder
10.3969/j.issn.1005-202X.2023.12.015
- VernacularTitle:低频rTMS联合帕罗西汀治疗对惊恐障碍患者临床症状和社会功能的影响
- Author:
Chengyu XU
1
;
Yufeng WU
;
Dan ZHOU
Author Information
1. 梧州市第二人民医院精神科,广西梧州 543001
- Keywords:
panic disorder;
low-frequency repetitive transcranial magnetic stimulation;
paroxetine;
clinical symptom;
social ability
- From:
Chinese Journal of Medical Physics
2023;40(12):1554-1557
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of the combination of low-frequency repetitive transcranial magnetic stimulation(rTMS)and paroxetine on clinical symptoms and social abilities in patients with panic disorder.Methods A total of 90 patients with panic disorder were randomly divided into observation group(n=45,low-frequency rTMS combined with paroxetine)and control group(n=45,paroxetine alone).All were continuously treated for 6 weeks.The clinical symptoms were evaluated with panic disorder severity scale(PDSS)and Hamilton anxiety scale(HAMA)for assessing the therapeutic effect;and the social abilities were evaluated with global assessment function(GAF)and perceived social support scale(PSSS).The occurrence of adverse reactions during treatment was recorded.Results After 4 and 6 weeks of treatment,compared with control group,observation group had lower PDSS score and HAMA score(Ftime=566.213,533.124,P<0.05;Fbetween-group=13.211,4.466,P<0.05),and higher GAF score and PSSS score(Ftime=486.312,497.112,P<0.05;Fbetween-group=62.601,123.510,P<0.05).After 4 and 6 weeks of treatment,the response rates in observation group were 80.00%and 91.11%,higher than 60.00%and 71.11%in control group(P<0.05).There was no significant difference in total incidence of adverse reactions between observation group and control group(22.22%vs 17.78%,P>0.05).Conclusion The combination of low-frequency rTMS and paroxetine can effectively relieve anxiety,improve clinical symptoms,therapeutic effect and social abilities in patients with panic disorder,with certain safety and bringing more benefits as compared with paroxetine alone.
