Analysis of influencing factors and prediction models of vancomycin AUC0-24h in postoperative orthopedic patients
10.12173/j.issn.1008-049X.202311261
- VernacularTitle:骨科术后患者万古霉素AUC0～24h影响因素分析及预测模型研究
- Author:
Hao YANG
1
;
Xiong XIONG
;
Changjiang LIU
;
Xiaoyue JIN
Author Information
1. 新疆医科大学第六附属医院药学部(乌鲁木齐 830001);新疆医科大学第六临床医学院药学教研室(乌鲁木齐 830001)
- Keywords:
Postoperative orthopedic surgery;
Vancomycin;
Area under curve for 24 h;
Predictive modeling
- From:
China Pharmacist
2024;27(1):66-75
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influencing factors of vancomycin in the area under curve for 24 h(AUC0-24h)in patients after orthopedic surgery,and to predictive and analyze a good pharmacokinetic model for AUC0-24h Methods Patients who underwent orthopedic surgery and used vancomycin in The Sixth Affiliated Hospital of Xinjiang Medical University from January 2018 to December 2022 were included,and the basic information,the medication,the blood and biochemical indexes of the patients were collected to analyze the factors affecting postoperative vancomycin AUC0-24h in orthopedic surgery.The AUC0-24h was calculated using the first-level pharmacokinetic formula,the JavaPK? for Desktop(JPKD)and the vancomycin daily dose elimination rate formula.Results 91 patients were finally included,and the cystatin C(OR=189.168,P=0.005)and the single dose(OR=19.160,P＜0.001)were independent protective factors for vancomycin AUC0 24 h in postoperative orthopedic patients,and the retinol binding protein was an independent risk factor for vancomycin AUC0-24h(OR=0.910,P＜0.05).By predicting and analyzing the model of vancomycin AUC0 24h in postoperative orthopedic patients,the absolute percentage error of both JPKD software and vancomycin daily dose elimination rate formula were lower than 30％.The intraclass correlation efficient between the AUC0 24h of the JPKD software and vancomycin daily dose elimination rate formula,and the AUC0 24h of the first-level pharmacokinetic formula were 0.781 and 0.524,respectively.Conclusion Cystatin C is an important factor influencing vancomycin AUC0-24h in postoperative orthopedic patients,and JPKD software is more suitable for predicting vancomycin AUC0-24h after orthopedic surgery than the vancomycin daily dose elimination rate formula method.
