Research advances in RNA methylation and regulation of cellular senescence

VernacularTitle:RNA甲基化调控细胞衰老机制的研究进展
Author: Chenyu ZHU ¹ ; Wenli CHENG ; Wenjuan ZHANG
Author Information

1. 暨南大学基础医学与公共卫生学院,广东广州 510632
Keywords: RNA methylation; cellular senescence; exogenous environmental factors; epigenetic toxic effects
From: Chinese Journal of Pharmacology and Toxicology 2024;38(3):212-219
CountryChina
Language:Chinese
Abstract: RNA methylation is a common epigenetic post-transcriptional modification with various patterns,such as N1-methyladenosine(m1A),5-methylcytidine(m5C)and N6-methyladenosine(m6A).RNA methylation can perform specific biological functions in corresponding targets,dynamical and reversible,thus bridging exogenous environmental factors and different disease outcomes.Exogenous chemicals can induce oxidative stress,inflammation,autophagy and cell cycle disorders,which are reg-ulated by specific RNA methylation modifications and bring about epigenetic toxic effects.These altera-tions act as new key molecular events during cellular senescence and the development of aging and age-related disorders.The correlation between RNA methylation and cell senescence will provide a new line of thought for prevention of and interventions in aging.