Research progress on phenotype and function of microglia
- VernacularTitle:小胶质细胞表型和功能研究进展
- Author:
Xiao-Tong WEI
1
;
Rui GUO
;
Qi-Chun ZHANG
Author Information
- Keywords: microglia; phenotype; function; disease-associated microglia; white matter-associated microglia; triggering receptor expressed on myeloid cells 2
- From: Chinese Pharmacological Bulletin 2024;40(3):410-415
- CountryChina
- Language:Chinese
- Abstract: Microglia are the central nervous system's resident myeloid-derived immune cells,which play a major role in the in-nate and acquired immunological responses of brain.In the ma-intenance of brain tissue function under both healthy and patho-logical conditions,microglia take a protective or damaging role,depending on cell phenotypes and functions.The traditional mi-croglia classification of pro-or anti-inflammatory phenotypes re-fers to the profile of macrophages,hence the term"brain macro-phages:has been drawn.More microglia phenotypes are being discovered as new technologies and research methods are devel-oped,and the newly discovered microglia phenotypes are often disease-,brain region-,and function-specific,providing an important foundation for studying the pathological processes un-derlying the development of specific diseases and developing ap-propriate interventions.Here,we provide a retrospective review of recent advances in the study of phenotype and function of mi-croglia,and analyze the microglial cell lineage composition and its heterogeneous function.
