Predictive values of IL-6 and IL-10 in the peripheral blood of donor of brain death for delayed graft function
10.12007/j.issn.0258-4646.2024.02.010
- VernacularTitle:脑死亡供者外周血IL-6和IL-10对移植肾功能延迟恢复的预测作用
- Author:
Shuai LI
1
;
Long BAO
;
Wenshi GUO
;
Ping SUN
Author Information
1. 锦州医科大学附属第一医院神经外科,辽宁 锦州 121000
- Keywords:
donor of brain death;
delayed graft function;
kidney transplantation;
interleukin-6;
interleukin-10
- From:
Journal of China Medical University
2024;53(2):149-152,159
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the predictive values of interleukin(IL)-6 and IL-10 in the peripheral blood of donors of brain death for delayed graft function(DGF)in kidney transplant recipients.Methods The clinical data and blood samples of 21 donors of brain death and 42 kidney transplant recipients were retrospectively collected.The predictive values of IL-6 and IL-10 in the peripheral blood of donors for DGF were evaluated using the occurrence of DGF as a dependent variable.Results Among the 42 kidney transplant recipients,10 developed DGF.Univariate analysis showed that there were significant differences in the IL-6 and creatinine levels in the donors and cold ischemia time of donor kidney between DGF and non-DGF groups.The receiver operating characteristic curve showed that IL-6 and IL-10 in donor peripheral blood had certain predictive values for DGF in kidney transplant recipients(AUC=0.82,95%CI:0.64-0.99;AUC=0.73,95%CI:0.51-0.95).Despite adjusting for creatinine level and cold ischemia time,IL-6 still has a certain predictive value for DGF.Conclusion IL-6 in the peripheral blood of donors of brain death may be a predictor of DGF in kidney transplant recipients.
